POSSIBLE EFFECTS OF THE HELICOBACTER PYLORI-ASSOCIATED NEUTROPHIL ACTIVATING PROTEIN

 POSSIBLE EFFECTS OF THE HELICOBACTER PYLORI-ASSOCIATED NEUTROPHIL ACTIVATING PROTEIN
In a recent publication in the World Journal of Gastroenterology, scientists are considering developing new drugs that target the Helicobacter pylori neutrophil activation protein, which this raises some concerns.

Helicobacter pylori episodic infectious agents promote the release of various chemoattractants / inflammatory mediators, including mainly the interleukin-8 neutrophil-binding substance and neutrophil activating protein, involved in helicobacter-induced gastric pathology.

Co-administration of Chios mastic, which inhibits H. pylori neutrophil activation protein, with a Helicobacter pylori eradication pattern could add clinical benefits to H. pylori-associated gastric pathologies without being the primary therapy. Regarding the study focused on neutrophil activation mediated by H. pylori neutrophil activation protein before and 2 months after CMG administration per os, the authors claimed that the results indicated a substantial decrease in the regulation of the inborn immune enhancement accompanied by significant clinical improvement of patients' symptoms for indigestion and gastric discomfort.

Although it appears that heterobacterial cytotoxin and neutrophil activating protein and other helicobacter-related cytotoxins play an important role in the creation and maintenance of H. pylori-associated gastric inflammatory response, and the neutrophil activating protein is a candidate for potential vaccination against Helicobacter pylori infection (H. Pylori-I), consideration should be given to its potential disadvantages, especially neurogenic.

The potential cross-imitation between H. Pylori neutrophil activation protein and / or bacterial aquaporin (AQP) and neural tissues may be associated with anti-AQP-4 antibody-related neural damage in patients with multiple sclerosis or visual neuromyelitis. A number of factors have been implicated in causing a blood-brain barrier disorder, including inflammatory mediators and oxidative stress. Cleavage of the blood-brain barrier allows for the access of T-lymphocytes and antibodies specifically to AKP4 to the central nervous system, thus playing a major role in the pathogenesis of multiple sclerosis.

Relevant studies show a strong correlation between helicobacter pylori and multiple sclerosis. Helicobacter induces humoral and cellular immune responses that, due to the distribution of homologous epitopes, react with nerve components, thus contributing to perpetuating neuronal tissue damage. Finally, the H. pylori neutrophil activation protein also plays a potential pathogenic role in both gastric and colorectal tumorigenesis.

Reference:
  • Kountouras J, Zavos C, Deretzi G, et al. Potential implications of Helicobacter pylori-related neutrophil-activating protein. World J Gastroenterol 2012;18:489-490.
Related product: L-Glutamine & Chios Mastic
Write your review
Please choose rating...

Please fill in name...

Please check the security field.
Thank you for your time. Your opinion is important to us! Your comment will be published soon.
Members Login
E-Mail Address:
Password:
Not a member yet?
New Customer?
By creating an account at the Natural Doctor you will be able to shop faster, be up to date on an orders status, and keep track of the orders you have previously made. The procedure is quite easy and fast. Try it.