Effect of glutamine on CROHN`s disease
Crohn's disease is a chronic inflammatory condition that affects a part of the gastrointestinal tract. Approximately 30-65% of patients with Crohn's disease have increased intestinal permeability, which is the cause of pathogenesis and relapses of the disease.
Glutamine is the main fuel and source of nitrogen for gut cells. The human intestine secrete about 13% of circulating glutamine which prevents increased intestinal permeability, bacterial translocation and maintains the integrity of the intestinal mucosa in a variety of diseases.
This clinical trial has been published in the Digestive Diseases and Sciences Journal and is a randomized, placebo-controlled trial involving patients with Crohn's disease in recessive phase with impaired intestinal permeability. Patients were randomized to two groups, the group receiving oral glutamine and the control group receiving serum protein 0.5 g / kg ideal body weight per day for 2 months. A total of 28 patients participated in the trial.
The intestinal permeability was evaluated by the urinary leak ratio (LMR) lactulose / mannitol and the morphometry was performed by computed image analysis.
A significant improvement in intestinal permeability after glutamine supplementation has been observed, and of great interest is an equal improvement with the group obtained whey protein, in both intestinal permeability and morphology. In the present study, a simultaneous improvement of the intestinal morphology was also observed. Glutamine has been previously reported as a nutrient for the small intestinal epithelia and a preferred fuel for the oxidative metabolism of enterocytes.
Both glutamine and whey protein significantly improved intestinal permeability and mucosal architecture in patients with Crohn's disease. High protein diets have been shown to be beneficial in patients with Crohn's disease and this study confirms that glutamine supplementation is just as effective in improving intestinal permeability in patients with Crohn's disease.
Benjamin, J., et al. 2012. Glutamine and whey protein improve intestinal permeability and morphology in patients with Crohn’s disease: a randomized controlled trial. Digestive diseases and sciences, 57(4), 1000-1012.
: L-Glutamine & Chios Mastiha