Bone health is age-related so over time is disrupted and affects a growing proportion of the population. Elderly patients with low bone density are at high risk of falls and fragility fractures, which in turn leads to high morbidity and subsequent mortality, with a consequent significant financial burden on the public health system. Prevention of age-related illnesses, including osteoporosis and related fractures, plays an essential role in the sustainability and a better quality of life.

Improved bone mass density (BMD) has been associated with a reduced risk of fracture and can lead to improved quality of life and also significant cost savings. With the increased osteoporosis rates in several countries over the last decade, primary prevention it is necessary to be established including strategies for restoring bone strength in patients with low bone mass density.

Clinical practice guidelines for the diagnosis and management of bone disorder have focused primarily on pharmacological therapy and lifestyle modifications to prevent fractures.

Scientific literature acknowledges micronutrients as integral parts of proper growth, physiology and bone retention. Insufficiency of nutrients necessary for bone health due to inadequate intake, digestive disorders or malabsorption may lead to impaired bone biology and a declined bone health. Recent research suggests that restoring nutritional deficiency and filling the various biochemical substances that are an integral part of healthy bone physiology can improve bone health.

Multiple studies have shown that beyond calcium and vitamin D, some other micronutrients have an impact on bone health. Among them, vitamin K2, strontium, magnesium and DHA appear to be involved in improving bone status.

This retrospective cohort study, published in the Journal of Environmental and Public Health, evaluated the value of using a combination of micronutrients in bone mineral density. 77 patients followed a proposed daily supplemental nutrition and exercise protocol, which included DHA from fish oil, vitamin D3, vitamin K2, strontium nitrate, magnesium, and dietary recommendations for increasing calcium intake and regular physical activity. As observed, an enhanced combination of micronutrients improves bone density in many patients who did not respond to bisphosphonate medications, as well as in patients who declined to start bisphosphonate therapy for reasons of choice or chemical sensitivity.

The decline in bone density is an essential indicator of bone health and is a determining factor associated with fractures. Integrated approaches to fracture prevention are necessary. In selected patients with impaired bone health, combined micronutrient therapy can be a promising alternative to pharmaceutical strategies to avoid further bone damage as well as to maintain or improve bone mass density.

  • Genuis, S. J., & Bouchard, T. P. (2012). Combination of Micronutrients for Bone (COMB) Study: bone density after micronutrient intervention. Journal of environmental and public health, 2012.
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